The E2NC Workshop will occupy one day of the Fifth International Green Computing Conference (IGCC 2014). There will be no separate registration for the workshop. All workshop attendees will be registering for the IGCC conference. All accepted papers will be published in workshop proceedings together with other workshops by the IEEE Computer Society Press and the IEEE online library. As part of the IEEE International Green Computing conference, a special workshop termed Energy-efficient Network on Chip, Multicore and Manycore Architectures will be organized to address various design aspects of power efficient and dependable computing infrastructures. Computing machinery around the world consumes staggering amounts of energy. The increasing power consumption of Integrated Circuits has plagued the semiconductor industry for years. Soaring power dissipations have proved to be the limiting factor for increase in performance. In the case of high-performance manycore devices, such as GPUs, power consumption and temperature issues prevent their mobile implementation. In addition, power and temperature issues reduce the reliability of semiconductor devices. Last, the communication and data exchange across these devices place extra pressure on their power budget. This has necessitated paradigm shifts in the IT and semiconductor industries at various levels. While major research is dedicated towards designing energy-efficient hardware, the aspect of reliability and dependability cannot be overlooked. This workshop will encompass a broad range of topics related to power efficiency and dependability of modern multicore, manycore and heterogeneous chips. Its objective is to facilitate exchange of valuable information and ideas among researchers and practitioners. The workshop will consist of invited presentations and contributed peer-reviewed research papers. The accepted contributions will appear in IEEE proceedings as a part of the IGCC 2014 conference proceedings of 6 page papers. The workshop will consist of invited presentations and contributed peer-reviewed research papers.