The 10th IEEE International Conference on e-Science, sponsored by the IEEE Computer Society's Technical Committee for Scalable Computing (TCSC), will be held in the Casa Grande Hotel, in Guarujá, SP, Brazil, from 20th – 24th October 2014. The way in which scientific research is carried out is undergoing a series of radical changes as a result of the digital revolution. Researchers in all disciplines are increasingly adopting digital tools, techniques and practices in communities and projects that span multiple disciplines, laboratories, organizations, and national boundaries. The e-Science 2014 conference is designed to bring together leading international and interdisciplinary research communities, developers, and users of e-Science applications and enabling IT technologies. The conference aims to serve as a forum to present recent research advances in e-Science and highlight associated activities worldwide, providing an outlook of challenges and opportunities we will face in the future.