Biology of the ZOMES - Proteasome, COP9 Signalosome and associated processes The ZOMES meetings focus on the biology of the three “PCI” complexes, the proteasome, the COP9 signalosome, and eIF3, and also additional complexes, such as E3-ubiquitin ligases, which interact with and are regulated by the PCI complexes. The study of large protein complexes -"ZOMES" - poses unique issues and difficulties, and the ZOMES meetings aim at providing a forum for discussing the connections between these complexes and central signaling pathways. The goal of ZOMES is to bring together researchers from diverse fields, who normally have no venue to meet, to initiate joint efforts for studying the functioning of these complexes. ZOMES meetings are unique in that scientists such as cancer researchers and plant scientists interact freely and exchange ideas, providing a forum for cross-fertilization which is absent in most specialized meetings.