Given the emerging global Information-centric IT landscape that has tremendous social and economic implications, effectively processing and integrating humungous volumes of information from diverse sources to enable effective decision making and knowledge generation have become one of the most significant challenges of current times. InformationReuse and Integration (IRI) seeks to maximize the reuse of information by creating simple, rich, and reusable knowledge representations and consequently explores strategies for integrating this knowledge into systems and applications. IRI plays a pivotal role in the capture, representation, maintenance, integration, validation, and extrapolation of information; and applies both information and knowledge for enhancing decision-making in various application domains. This conference explores three major tracks: information reuse, information integration, and reusable systems. Information reuse explores theory and practice of optimizing representation; information integration focuses on innovative strategies and algorithms for applying integration approaches in novel domains; and reusable systems focus on developing and deploying models and corresponding processes that enable Information Reuse and Integration to play a pivotal role in enhancing decision-making processes in various application domains. The IEEE IRI conference serves as a forum for researchers and practitioners from academia, industry, and government to present, discuss, and exchange ideas that address real-world problems with real-world solutions. Theoretical and applied papers are both included. The conference program will include special sessions, open forum workshops, panels and keynote speeches.