The 2014 Gordon Research Conference on Ion Channels will continue the long tradition of bring together leading researchers to share unpublished, cutting-edge biomedical research focused on the proteins responsible for ion transport. The 2014 scientific program will cover all aspects of ion channel biology and biophysics, including the structure and regulation of ion channels, protein biogenesis and trafficking and integrated aspects of ion channels in physiological function. Invited Speakers have been selected to ensure a diverse set of topics, channels and presenters. All participants are asked to submit an abstract for presentation in the poster session and approximately ten short talks will be chosen from the abstracts. We strongly encourage graduate students and post-doctoral fellows to apply to both the 2014 Ion channels GRC and to the GRS held immediately before the meeting. Selected abstracts from these early-career investigators will be chosen for presentation in a short 2 minute "Data Blitz", a very popular feature at the 2012 GRC. A main goal of the meeting is to stimulate in-depth discussions among all attendees, giving rise to new ideas and directions for the field. Interactions are promoted by programming a generous amount of time for discussion sessions and by providing opportunities for informal gatherings at meals and in the afternoons and evenings. The 2014 meeting will be held at Mt Holyoke College in idyllic Western Massachusetts. Mt Holyoke College is within easy driving distance from Boston's Logan Airport, and a shuttle bus will provide transportation prior to and at the conclusion of the meeting. Travel awards are available for selected postdoctoral associates, graduate students, and minority participants.