The Gordon Research Conference on Lipoprotein Metabolism is one of the longest standing conferences in the 80-year history of the GRC. The scientific content of our conference has continually evolved since the first meeting and, traditionally, is considered the preeminent forum in our discipline for the presentation of high impact leading edge science. The program for the 2014 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a spectrum of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact upon human disease. Basic molecular and cell biological studies, animal models of metabolism, and genetic studies in humans will be presented. Topics include lipases, hepatic and intestinal lipid metabolism, HDL and reverse cholesterol transport, lipoprotein receptors and the vascular wall, CNS lipid metabolism, intracellular lipid metabolism and lipid droplets, genetics of lipid and lipoprotein metabolism, and therapeutics of lipid and cardiovascular disease. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. There will be a keynote speaker, and additional Oral Session presentations will be selected from among submitted abstracts.