On behalf of the Organising Committee we welcome you to Melbourne, ranked by the Economist Intelligence Unit in 2011, 2012 and 2013 as the most liveable City in the world, to Australia, and to the 2014 IEEE International Symposium on Circuits and Systems. ISCAS’2014 is sponsored by the Institute of Electrical and Electronic Engineers Circuits and Systems Society (IEEE CASS), and generously supported by the State Government of Victoria and the Melbourne Convention Bureau. As you all know, ISCAS is the flagship annual conference of IEEE CASS, and it is well established as the world’s premier networking forum in the fields of theory, design and implementation of circuits and systems. As a result of the release of its 2012 Vision and Mission (see ieee-cas.org), the CASS goal is to develop ISCAS also as the leading forum for pioneering circuits and systems contributions to humanity’s grand challenges. Accordingly, the special theme of ISCAS 2014 is nano/bio circuits and systems applied to enhancing living and lifestyles, particularly in relation to the multidisciplinary grand challenges in healthcare and wellbeing, the environment and climate change.