It is widely established that it is essential to understand the dynamics and mechanisms of biomolecular interactions in order to develop methods for efficiently monitoring biological activities, designing new functionalities or altering existing properties. Fundamental principles of physical sciences, polymer science and engineering have played a crucial role in molecular and structural biology in establishing the physical basis and origin of complex interactions. Significant advances have been made in recent years, both computationally and experimentally. However, the cooperative dynamics and evolutionary properties of biological systems, as well as the effect of the physiological (crowded) environment present additional layers of complexity, which are limiting our ability to elucidate the mechanisms of function and allostery that underlie many observed phenomena. These complications are best reflected in the characterization of membrane proteins and biomolecular machines often composed of multiple subunits that act concertedly in restricting environments. The development of effective strategies for identifying the molecular origin and mechanisms of observed phenomena and for developing intervention methods for regulating or modifying biological function requires a deeper level of quantitative investigation and multidisciplinary collaboration. The proposed GRC is uniquely poised to bring together scientists from different disciplines and foster new collaborations toward this aim. A preliminary program outline is available below. Additional presentations (short talks and poster) will be selected from submitted abstracts. Please submit your abstracts and check back for updates.