Following the success of ISACS-1 (International Symposium on Advancing the Chemical Sciences) in San Francisco (2010) and ISACS-7 in Edinburgh (2012), ISACS-14 Challenges in Organic Chemistry will take place at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, during August 07 (Thurs)-10 (Sun), 2014. 　　ISACS-14 will bring together world leading experts in the field of organic chemistry and provide an outstanding program, complimented by extensive poster sessions forming a key part of the symposia. There will be questions after each talk and delegates will be exposed to new areas of research which will encourage the cross fertilization of ideas. 　　On behalf of the organizing committee, I cordially invite you to take part in ISACS-14 and look forward to welcoming you to Shanghai.