The Asian monsoon region is uniquely affected by global climate change, drawing international attention to the magnitude and scale of climate variations and their impacts on the nations of the region. The MAIRS (Monsoon Asia Integrated Regional Studies) programme was established in 2006 to specifically address the interactions between climate and human systems in the monsoon Asia region, using interdisciplinary approaches to integrate research on human communities, climate and ecosystems. By focusing on the integrated studies in three vulnerable zones (Coastal Urban, Mountain, and Dryland), the MAIRS programme has achieved a significant understanding how the climate-human system interacts but at the same time identified knowledge gaps. The 2014 MAIRS Open Science Conference, to be held in Beijing China, provides a platform for scientists, stakeholders, policy makers, and public in general to present the state-of-the-art findings and challenges in addressing climate change issues in the Monsoon Asia.