Fourteen previous Florida Conferences held each March for the years 2000 through 2013 inclusive, brought together the academic and industrial communities with an abundance of heterocyclic and synthetic chemistry reflecting the current interest in the subject. The program holds particular interest for the industrial chemical community since pharmaceuticals, agrochemicals and colorants usually contain at least one heterocyclic ring. This, the 15th Florida Heterocyclic and Synthetic Conference, continues in the tradition of its highly successful predecessors. Registration will start on Sunday, March 2nd with a Welcome Reception. On Monday the 3rd through Wednesday the 5th, the Conference will feature eleven plenary lectures given by academic and industrial experts from around the world together with invited lectures and a short course on catalysis and heterocyclic chemistry. A poster session combined with a buffet supper will be held on the evening of Monday, March 3rd. A wine reception and conference banquet are scheduled for the evening of Tuesday, March 4th. The conference closes with a farewell party on the evening of Wednesday, March 5th.