The 2013 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS 2013) will be held in Houston during November 17-19, 2013. GENSIPS 2013 will provide a forum for signal processing researchers, bioinformaticians, computational biologists, biomedical engineers, and biostatisticians to exchange ideas and discuss the challenges confronting computational bioinformatics and systems biology communities due to the high modality of disparate high-throughput data, high variability of data acquisition, high dimensionality of biomedical data, and high complexity of genomics and proteomics. GENSIPS 2013 will feature prominent plenary speakers in biomedical research.