The 6th IEEE International Conference on Cybernetics and Intelligent Systems (CIS) will be held, together with the the 6th IEEE International Conference on Robotics, Automation and Mechatronics (RAM), under the official umbrella of the inaugural IEEE conferences on CIS & RAM, from Saturday to Monday, November 12-15, 2013 at Manila, Philippines. The goal of the CIS 2013 is to bring together experts from the field of cybernetics and intelligent systems to discuss on the state-of-the-art and to present new research findings and perspectives of future developments with respect to the conference themes. The conference welcomes paper submissions from researchers, practitioners, and students in but not limited to the following areas: Cybernetics Automation and Control, Cooperative Systems and Control, Multi-Agent Systems, Discrete Event Systems, Supervisory Control, Hybrid Systems, Networked Dynamical Systems, Mechatronics. Intelligence Computational Intelligence, Swarm Intelligence, Soft Computing, Fuzzy Systems, Neural Networks, Genetic Algorithm, Evolutionary Computation, Image Processing, Computer Vision. Systems Modeling & Control, Smart Sensor Networks, Environmental Systems, Systems Biology, Cyber-physical Systems, Human/Machine Systems, Transportation Systems, Power Systems, Manufacturing Systems, Decision Support Systems, System of Systems.