The 2013 IEEE SMC will be held in Manchester, in the heart of England. This city offers a unique combination of both historical and modern aspects of British culture. The conference venue is located in downtown Manchester, near the railway station and business district. The 2013 IEEE SMC provides an international forum for both researchers and practitioners to report their latest innovations, summarize state-of-the-art in the field, as well as exchange ideas, results, and visions in all fields of systems engineering, cybernetics, and human-machine systems. Organized according to those three principal SMC areas, the conference calls for papers on the technical topics listed below. Contributions ranging from theoretical results to practical or industrial applications are strongly encouraged.