Faults/failures in technical systems may have many undesired consequences as damage to technical parts of plants, endangering of human life or pollution of the environment. Equipment failures may also have profound negative impact on production costs and product quality. The development of fault diagnosis methods allowing early detection of faults/failures is crucial in order to protect complex manufacturing machineries, to increase human life safety and to support decision making on emergency actions and repairs. Moreover, in highly automated industrial systems where maintenance or repair cannot be carried-out immediately, it is crucial to employ fault-tolerant control systems capable of ensuring acceptable performance even in the presence of faults. The conference will bring together academics, engineers and practitioners active in the fields of fault diagnosis, fault tolerant control and their application in process monitoring and maintenance. The conference main aims are: to showcase current research results and recent developments of intelligent techniques; to present practical applications and emphasize open problems; to provide a forum for industry to signal its needs and priorities. Three years ago, the 1st International Conference on Control and Fault-Tolerant Systems (Systol’10) was a success and demonstrated the demand for establishing a permanent scientific forum in the general area of system monitoring, fault diagnosis and fault-tolerant control. The Second conference on Control and Fault-Tolerant Systems (Systol’13), through its technical program, will provide a unique opportunity for the academic and industrial community to formulate new challenges, share solutions and discuss future research directions. Presentations of theoretical results accompanied by practice related experiments are encouraged.