Digital Ecosystems inherit concepts of open, loosely coupled, demand-driven, domain clustered, agent-based self-organized collaborative environments where species/agents form a temporary coalition (or longer term) for a specific purpose or goals. Within this environment every agent is proactive and responsive for their own benefit or profit. The essence of digital ecosystems is inspired by ecological and biological system concepts, and creating value by making connections through collective intelligence and promoting collaboration instead of unbridled competition and ICT-based catalyst effects in a number of domains, to produce networked enriched communities, humanities and societies. In the present Digital Age, strong development of digital network infrastructure has dominated our service delivery, economic growth and life style. Future applications in domains such as Health-Care, Energy, Transportation and Data-Incentive society demand infrastructures that are more agile than those operated currently. Digital Ecosystem Technologies encompass Human Space Computing and Cyber Information Engineering, starting from Web 3.0 to Web of Things, from Heterogeneity to Elasticity, from Internet of Things to Cloud of Things which has become a major theme for digital economy and digital society. IEEE DEST conference series has the highest citation rate among all IEEE-IES conferences. IEEE Transactions on Industrial Informatics and IEEE Transactions on Industrial Electronics publish special sessions for this conference. In 2013, the distinguished SEED Inauguration Workshop "Building a Digital Ecosystem for Societal Empowerment" will take place in cooperation with IEEE DEST 2013. Further, the Innovation Adoption Forum underpins the importance of public-private partnership as the key for delivering sustainable solutions for our Complex Living and Business Environment – and thus our Digital Ecosystem Habitat. Our Keynotes, Panels and Sessions will tackle the multifaceted challenges and solutions from various stakeholders’ perspectives.