Cognitive Informatics (CI) is a cutting-edge and multidisciplinary research field that tackles the fundamental problems shared by modern informatics, computing, AI, cybernetics, computational intelligence, cognitive science, intelligence science, neuropsychology, medical science, systems science, software engineering, knowledge engineering, cognitive robots, scientific philosophy, computational linguistics, and life sciences. Cognitive Computing (CC) is a maturing paradigm of intelligent computing methodologies and systems based on cognitive informatics that implements computational intelligence by autonomous inferences and perceptions mimicking the mechanisms of the brain. CI and CC are a transdisciplinary enquiry on the internal information processing mechanisms and processes of the brain and their engineering applications in cognitive computers, computational intelligence, cognitive robots, cognitive systems, and in the AI, IT, and software industries. The development and the cross fertilization between the aforementioned science and engineering disciplines have led to a whole range of extremely interesting new research areas known as CI and CC. Following the first ten successful conferences on Cognitive Informatics (ICCI’02 through ICCI’10, then ICCI*CC'11 and ICCI*CC'12), the 12th IEEE Int’l Conference on Cognitive Informatics and Cognitive Computing(ICCI*CC’13) focuses on the theme of Cognitive Computers and Knowledge Processors. ICCI*CC’13 welcomes researchers, practitioners, and graduate students to join the international initiative on cognitive informatics and cognitive computing toward the investigation of cognitive mechanisms and processes of human information processing, and the development of next generation computers that learn and think.