Information is widely available and accessible, but frequently leads to information overload and overexposure, while the effort for coding, storing, hiding, securing, transmitting and retrieving it may be excessive. Intelligence is required to manage information and extract knowledge from it, inspired by biological and other paradigms. Multimedia Systems and Networks, with an increasing level of Intelligence, are being developed that incorporate these advances. As a result, new Technologies, Protocols and Applications are emerging. The International Conference on Information, Intelligence, Systems and Applications (IISA) series offers a forum for the constructive interaction and prolific exchange of ideas among scientists and practitioners from different research fields – such as computers, mathematics, physics, biology, medicine, chemistry, experimental psychology, social sciences, linguistics, and engineering – having the goal of developing methodologies and tools for the solution of complex problems in artificial intelligence, biology, neuroscience, security, monitoring, surveillance, healthcare, sustainability in energy sources, governance, education, commerce, automation, robotics, optimization, image, speech and natural languages, and their integration. IISA-2013 is the fourth conference in the IISA series, technically co-sponsored by IEEE and BAIF and hosted by the University of Piraeus in Piraeus-Athens, Greece. IISA Proceedings will be published by IEEE. The conference is intended as an international forum for researchers and professionals in all areas of Information, Intelligence, Systems and Applications. We invite submissions of papers presenting high-quality original research and developments for the conference tracks listed below. The conference will last for three days and will feature tutorials, technical paper presentations, workshops, and distinguished keynote speeches.