Enterprises must collaborate in order to prosper in the current extreme dynamic and heterogeneous business environment. Enterprise integration, interoperability and networking are the major disciplines that study how companies collaborate, communicate, and coordinate in the most effective way. These disciplines are well-established and supported by international conferences, initiatives, groups, task forces and European projects where different domains of knowledge are involved from different points of views and according to a variety of objectives (e.g., technological or managerial). Enterprise Integration aims at improving synergy within the enterprise so that business goals are achieved in a more productive and efficient way. Enterprise Interoperability and Networking involves breaking down organizational barriers to improve synergies across organizations to achieve more productive collaboration. Enterprise modelling, architecture, and ontology are the pillars supporting the achievement of enterprise integration and interoperability.