The Twenty-Fifth International Conference on Software Engineering and Knowledge Engineering (SEKE 2013) will be held at Hyatt Harborside at Boston's Logan International Airport, USA from June 27 to June 29, 2013. The conference aims at bringing together experts in software engineering and knowledge engineering to discuss on relevant results in either software engineering or knowledge engineering or both. Special emphasis will be put on the transference of methods between both domains. Submission of papers and demos are both welcome.