Cyber-physical systemsare tight integrations of computation, networking, and physical objects. Recent advances in pervasive and ubiquitous information processing, driven by major breakthroughs in cyber-physical technology are paving the way towards a more hospitable and sustainable future via a more efficient management of our environment: homes, work places, open areas, etc. Examples of relevant applications include: future automotive and transportation systems featuring intensive sensing and open data communication devices, robot-assisted communication and cooperation in search and rescue missions, enhanced situation awareness in public urban spaces, assistance and monitoring in everyday life for elderly or handicapped people, smart resilient and secure heterogeneous energy grids, etc. It is envisioned that the requirements of the CPS of the future will far exceed those of today’s systems in terms of functionality, usability, adaptability, autonomy, timeliness and resilience to accidental and malicious threats as well as to dynamic changes of user behaviors and of the environment. For this to become a reality, several scientific challenges have to be addressed, among which we can list the followings: The need for multidisciplinary approaches integrating technological concerns including physical system dynamics and information and communication technologies related aspects (covering topics such as sensor technologies, communication and networking, optimization, control and decision making algorithms, resilience and quality of service enforcement and assessment), and human concerns related to human-physical system interaction, usability, user experience, responsibility, privacy, security and user and social acceptability. The need for human-aware self-adapting approaches to adapt autonomously, at least reactively and as much as possible proactively, the provided behavior to dynamic changes in the system behavior, environment or threats. The need for an integration of design & assessment activities to build the optimal architectures and configurations able to provide the best tradeoffs between functional requirements and non-functional requirements (reliability, availability, security, timeliness, performance, etc.) The aim of this workshop is to set up in the framework of DSN a forum for researchers and practitioners, to address these challenges and to report on recent advances related to the dependability and security of human-aware CPS.