The sixth International Symposium of Domain Theory and Its Applications will take place on the campus of Hunan University in Changsha, China, from October 25 to October 29, 2013 (the first ISDT was held in Shanghai, October 17-24, 1999; the second ISDT was held in Chengdu, China, October 22-26, 2001; the third ISDT was held in Xi'an, China, May 10-14, 2004; the fourth ISDT was held in Changsha, China, June 2-6, 2006; the fifth ISDT was held in Shanghai, China, September 11-14, 2009). This conference is intended to be a forum for researchers in domain theory and its applications. The conference series also aims to broaden its scope of applications in computer science and mathematics.