The ACM International Symposium on High-Performance Parallel and Distributed Computing (HPDC) is the premier annual conference for presenting the latest research on the design, implementation, evaluation, and the use of parallel and distributed systems for high-end computing. The 22nd HPDC will take place in the heart of iconic New York City at the New Yorker hotel, on June 17-21, 2013. HPDC'13 features a technical program with sessions on: I/O and Data-Intensive Computing, Networks, Communication, Checkpointing, Bugs and Errors, Multicore and GPUs, and Virtualization and Clouds; three distinguished keynote speakers (Garth Gibson, CMU and Panasas, Inc.; David Shaw, Chief scientist of D. E. Shaw Research, and Miron Livny, University of Wisconsin-Madison); an industry session (Oscar Boykin, Twitter, Blake G. Fitch, IBM Research); and seven associated workshops: EEHPDC, FTXS, CLHS, HPPN, OrmaCloud, ScienceCloud, and VTDC