The 2013 Phagocytes Gordon Conference will bring together scientists from around the world to discuss the most recent advances in the field. Expert invited speakers will present their latest unpublished research related to the many facets of phagocyte biology. Featured topics will include macrophage functional genomics, mathematical modeling and in vivo analysis of neutrophil polarity and migration, host-pathogen interactions, inflammasomes, phagocytosis and autophagy, functional and phenotypic plasticity of phagocytes in the tumor microenvironment and the brain, and exciting advances in our understanding of phagocyte interactions with and effect on other cell types during infection, inflammation and sepsis. The program is designed to encourage vigorous discussion and the free exchange of ideas. Thus, each scientific session will be chaired by a prominent researcher who will highlight recent progress and knowledge gaps related to each topic, and guide subsequent discussion. As participation of junior scientists is a key goal of the meeting, the conference will also include two interactive sessions for presentation of ~90 posters, and additional speakers will be chosen from among the submitted abstracts. The collegial atmosphere of this conference is exemplified by the shared meals, and the substantial time provided for informal gatherings in the afternoons and evenings to further promote interactions between attendees at all levels. The overall environment is therefore designed to provide multiple opportunities for learning and for the development of relationships and collaborations. To facilitate the participation of students and postdoctoral fellows, the conference will be preceded by a Gordon Research Seminar (GRS). The Phagocytes GRS is planned by and for trainees, and provides an opportunity for our future leaders to present their research via seminars and posters in a supportive and interactive environment. The GRS has been well received and adds substantial value to the Gordon Research Conference experience for these junior investigators.