We are pleased to host the fourth Cold Spring Harbor meeting on Computational Cell Biology, which will begin in the evening of Tuesday, March 19, and run through lunch on Friday, March 22. The specific goal for this meeting is to foster fruitful and creative interactions between experimental cell biologists and mathematical/computational scientists who have common interests in the dynamics of cellular processes. All stages of the modeling process will be represented at the meeting, from data generation in experimental cell biology, to data analysis and computer simulation, to the development and validation of quantitative models describing the data, to the models informing further experimentation. The meeting will consist of eight oral sessions plus a poster session and software demonstrations.