The principal aim of this conference series is to present to an international community cutting edge developments in epigenetics and epigenomics. This meeting comes as a continuation of other three very successful conferences in this series. As epigenetics research is rapidly evolving the meeting plans to include also functional genomics and systems biology topics. This should provide a unique bridge to bring epigenetics and the systems biology community together for intense discussion and interactions. This pluridisciplinary angle should be most stimulating to develop collaboration and creative new lines of research.