The second installation of this new GRC brings together researchers working on problems at the interface between biology and physics. Recent studies have shown that the behaviors of many biological systems are not deterministic; rather, they are driven by stochastic effects that emerge in the limit of small molecule numbers. The discovery of phenomena not predicted by classic deterministic dynamics is driving exciting new areas of research in biology. Topics at this GRC will focus on both theoretical and experimental approaches that address foundational questions about stochasticity in living systems. In particular, areas of research in studies of biological noise, nonlinear dynamics, and emergent behaviors at different time scales will be highlighted. This conference is designed to maximize discussions and interactions among researchers in diverse disciplines. Tentative sessions: Foundations and current approaches; Stochasticity, physics and biology; Emergent phenomena in cell biology; Fluctuations and stochasticity at all scales; Thermodynamics and stochastic open systems; Stochastic dynamics and molecular biology; Force, mechanics, and cell biology; Biological dynamics in space and time; Stochastic nonlinear dynamics, models and computations