The Human Genomics and Personalized Medicine meeting will be co-chaired by Drs. Kelly A Frazer and Geoffrey Ginsburg who respectively are leaders in the field of human genomics and personalized medicine. We have selected a diverse set of speakers based on their expertise who we believe can present a balanced and complementary view of the field. The meeting will have eight sessions highlighting: 1. Breakthroughs in Genomic and Personalized Medicine; 2. Genomes and Biology; 3. Policy; 4. Advances and Challenges in the Field; 5. Pharmacogenomics; 6. Personalized Genomes; 7. Cancer Genomics and Applications; and 8. Translating Biomarkers to Personalized Medicine. For the “Breakthroughs in Genomic and Personalized Medicine” session to be as timely as possible we have left two spots open with the goal of choosing speakers in 2012 closer to the time of the meeting. The Genomes and Biology session includes talks on the role of inherited variants, the epigenome and microbiomes in disease. For the Policy session we have chosen experts to discuss consumer expectations and economic drivers for Personalized Medicine. Advances and Challenges in the Field includes talks on the key regulatory issues, analysis of complex data sets, developing robust biorepositories and public access to large data sets being generated on funds from NIH and other agencies. The Pharmacogenomics session features leaders in the field who are actively working in bringing genomic targeted therapies to the clinic in a variety of diseases. For the Personalized Genomes session leading experts using whole genome sequences for clinical trials and diagnostics will present. The Cancer Genomics and Applications session includes a representative of The Cancer Genome Atlas NIH sponsored program, an industry talk on successful translation of a commercial genomics diagnostics and two targeted therapy talks, one of which is focused on cancer stem cells. The Translating Biomarkers to Personalized Medicine session has three individuals from industry utilizing genome sequence data to develop diagnostics and for drug discovery. Finally, The Future of Genomic Medicine, a keynote address given by a leading government official who will discuss science and science policy with an emphasis on what the government doing to advance Personalized Health Care.