Data mining is the computational process for discovering valuable knowledge from data – the core of Data Science. It has enormous application in numerous fields, including science, engineering, healthcare, business, and medicine. Typical datasets in these fields are large, complex, and often noisy. Extracting knowledge from these datasets requires the use of sophisticated, high-performance, and principled analysis techniques and algorithms, which are based on sound theoretical and statistical foundations. These techniques in turn require implementations on high performance computational infrastructure that are carefully tuned for performance. Powerful visualization technologies along with effective user interfaces are also essential to make data mining tools appealing to researchers, analysts, data scientists and application developers from different disciplines, as well as usable by stakeholders.