188 / 2019-06-29 10:59:55

Electrical and viscoelastic measurement of cancer cells in epithelial-mesenchymal transition process on a microfluidic device

Microfluidics, EMT, viscoelasticity, Electrical properties

Microfluidic devices and electrical techniques based on electrical impedance and viscoelastic changes can be used in the measurement of cancer cells in the epithelial-mesenchymal transition (EMT) process. Electrical impedance and transmission time were investigated when a single CRC cell passed the measurable tiny channel which was designed with width smaller than the average diameter of a single cell. The experimental data showed that the electrical impedance characteristics and viscoelasticity of the cells were changed after PMA induction. This property is expected to become a new biomarker for studying EMT.