In this current technological era, a huge amount of medical and biological data has been managed electronically and it has demanded the seamless availability of E-health applications anywhere anytime. This demand has paved the ways for modern healthcare technologies deployment in telemedicine and mobile healthcare services. While on the other hand, this rapidly evolving technologies and their deployment in healthcare systems also pose many unseen threats disguised in this technology giant. And these might affect the conducive working environment of a healthcare organization and its smooth processes from patient’s data privacy to healthcare records protections and their secure transmission among various healthcare locations. These unseen treats could be due to the vulnerabilities inherited/disguised in any of the technology parameter or service delivery mechanisms that appear with the time after the technology is deployed. Since by the time, the critical healthcare processes would be relying on the newly deployed technology; appearing such issues would affect adversely and become intolerable. Many healthcare organizations have faced numerous loses including public confidence due to these security flaws in recent years. Although the security efforts and technologies have evolved significantly but it still remains a challenging task (due to novel unseen and continuously emerging threats) and requires a continuous struggle to address these issue. The other significant reason is the repeated and sophisticated security attacks that continuously introduce malicious softwares and pose threats to patient’s data privacy and healthcare security.