1 / 2016-06-14 10:54:04

Subjective cognitive function across manic or hypomanic, depressed, and euthymic states in Chinese bipolar disorder patients.

10397,10398,10399,10400

Although evidence has shown that bipolar patients have objective cognitive impairments in different clinical states such as manic or hypomanic, depressed, and euthymic states, little information exists about the subjective complaints of bipolar patients regarding cognitive impairment across different clinical states. The present study aimed to address the subjective cognitive function across different states of bipolar illness and to explore relationships among subjective and objective cognitive function and psychosocial functioning. The subjective and objective cognitive function and psychosocial functioning were examined in 48 manic or hypomanic bipolar patients, 42 depressed bipolar patients, and 50 euthymic bipolar patients. The healthy controls group consisted of 60 participants without history of neurological or psychiatric disorders. The measurements included the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and Global Assessment Function (GAF), and a neuropsychological battery assessed attention, executive function, verbal and visual memory. The depressed bipolar patients (21.26 ± 6.59) experienced significantly higher COBRA score than the other three groups (F = 53.62, p < 0.001) and all patient groups showed more subjective complaints than the healthy group (p < 0.01). The variables that better predicted psychosocial functioning in all bipolar patients were the COBRA (t = -8.50, B = -4.473, p = 0.000) and the executive function (t = -4.03, B = -2.127, p = 0.000). In conclusion, the depressed bipolar patients were experienced more subjective cognitive impairment than other bipolar patients; and the variables that best predicted psychosocial functioning in bipolar patients were the subjective cognitive function and executive function.