“Atlantification”, as a newly found phenomenon recently, is characterized by significant ocean warming and weakening in the upper ocean stratification along with winter sea ice decline in the Atlantic sector of the Arctic Ocean, especially in the Barents Sea and Eurasian Basin. To understand the future evolution of Atlantification in potential warming climate, we carried out model experiments with the AWI Climate Model by applying regionally increased CO₂ concentrations in different latitudinal belts. It turns out that the ocean basins in the (sub-)polar region of the Atlantic sector would go through the most significant changes no matter the CO₂ increase is applied in high latitude, mid-latitude or globally. The winter sea ice coverage in the Barents Sea would shrink polarward with continuous climate warming, the Eurasian Basin would also have dramatic sea ice decline in winter if strong global warming occurs in future. The profound ocean warming and upper ocean stratification weakening in the Barents Sea and Eurasian Basin are also found in all model simulated different warming scenarios. Our study implies that the Barents Sea and Eurasian Basin are key regions for Atlantic-Arctic climate regime in future warming climate.