As cities are complex systems, they show emergent behaviour and are only partly planable. With increasing numbers of people living in cities, though, the pressure to make cities more liveable places and find solution for reaching the sustainable development goals, is high. The systems approach to urban health and wellbeing can offer pathways towards solutions: Integrated urban planning for health, connects various urban sectors which all have effects on human (social, mental, physical) health. Understanding these complexities requires computerised system tools to disclose the underlying rules of emerging patterns of interconnectivity. In the social sciences these are rules of behavior, or institutions. The systems approach to urban health and wellbeing, apart from putting health into the center of integrated urban planning, combines the use of algorithms and institutions for sustainability.