95 / 2018-08-07 15:29:31

Ice-templated biomimetic materials for bone tissue engineering

Biomimetic,Scaffold,Bone,Cell seeding,Freeze-casting

全体主题 > vi. BAMOS (Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation)

One of the most important issues in bone tissue engineering is searching for new materials and processing techniques to create novel scaffolds with 3-D porous structures. Ideal bone scaffolds should have good biocompatibility, biodegradability, and beneficial mechanical properties. In our research, we use an ice-templating method, attempting to build biomimetic bone implants that adapt to physiological conditions, interact with surrounding tissues, and repair themselves. Most recently, we developed a bidirectional freezing technique to achieve hydroxyapatite (HA) scaffold with large-scale aligned porous structure, which could be beneficial for improving cell seeding and migration. By further infiltration such scaffolds with poly (methyl methacrylate) (PMMA), we have fabricated a HA/PMMA composite with nacre-mimetic alternative layered architectures. Such composite has similar composition and mechanical properties with human cortical bone, which make it a promising candidate for bone implants.