64 / 2018-07-30 17:09:49

Preparation of PDA/TiO2 Composite Film on PTFE by Two-step Method and Its Cellular Response

composite film,PTFE,cell response

全体主题 > ii. Biomaterials and formulation of novel “bioinks” for tissue-specific applications

Polytetrafluoroethylene (PTFE) has good mechanical properties, chemical stability and biocompatibility, and does not cause the body's rejection[1]. However, as one of the main materials in rhinoplasty prosthesis and artificial blood vessels, the low surface energy makes PTFE uneasy to interact with cells. That needs to be improved[2], forming a layer of TiO2 film on the surface of PTFE is believed to be able to improve that, but it is difficult to obtain a layer of TiO2 film directly on the surface of the substrate. The newly discovered polydopamine(PDA) makes it possible to perform a simple and effective surface modification, since dopamine can act as an intermediate to immobilize other materials or molecules through self-polymerization.
In this work, A PDA/TiO2 composite film was prepared on the surface of PTFE substrate by in-situ co-deposition method. The surface of the prepared film was uniform, and the content of TiO2 in the film could be controlled by the mixing ratio of the two solutions. The film was firmly bonded to the substrate. The presence of TiO2 in the films prepared by different methods was confirmed by Raman spectroscopy and water contact angle test before and after UV irradiation, and the hydrophilicity of the modified substrate was improved. 1-day cell adhesion experiment and 3-day cell proliferation experiment showed the PDA/TiO2 composite film had better biocompatibility than the pure PTFE substrate.