ollaborative research and innovation is the organizational behavior to realize the enterprise, institutions of higher learning and scientific research institutes and so on other innovation subjects complementary advantages, and improve the technological innovation ability, and the scientific and reasonable distribution of interests is the key of collaborative innovation to smooth implementation. First of all, based on influencing factors of interest coordination, to build a cooperative innovation model of interest coordination; Secondly, based on game equilibrium solution and the optimal allocation coefficient, using MATLAB software to carry out numerical simulation, to verify the theoretical results of correctn