3 / 2016-07-08 21:31:49

The clinical application of PCT in the cerebrospinal fluid of post craniocerebral operation intracranial infection

traumatic;injury brain;procalcitonin;intracrinial infection

Objectives To research the clinical application of procalcitonin (PCT) in the cerebrospinal fluid of post craniocerebral operation intracranial infection . Methods Collected the cerebrospinal fluid and blood samples of the patients which post craniocerebral operation with intracranial infection (30 cases) and post craniocerebral operation without intracranial infection (30 cases) in our department from May 2013 to November 2015, detected the procalcitonin and white blood cells in cerebrospinal fluid and PCT and white blood cells in blood and then analyzed statistically. The patients with intracranial infection (30 cases) all underwent regular anti intracranial infection treatment one week. The therapeutic results are divided into effective group (25 cases) and ineffective group (5 cases). Detected the PCT in cerebrospinal fluid the day before the treatment and that at 1, 3, 7 days after treatment, and then analyzed statistically. Results The PCT in cerebrospinal fluid and blood and white blood cells in cerebrospinal fluid which in intracranial infection group were significantly higher than non-infected group (P <0.05). The difference of the white blood cells in blood was not statistically significant. The PCT in cerebrospinal fluid which the patients had intracranial infection with effective anti-infection treatment group was decreasing gradually, and the PCT in cerebrospinal fluid of the ineffective group was increasing gradually (P<0.05). Conclusions The PCT and white blood cells in cerebrospinal fluid and PCT in blood all had significance in diagnosis of post craniocerebral operation intracranial infection. And the PCT in cerebrospinal fluid had higher sensitivity , it had greater clinical value .