This study analyzes teachers and students’ feedback to interaction and knowledge in the classroom, and designing the classroom interaction system. That based on investigating the classroom interaction system of domestic and foreign and theoretical analysis, combined with the practical application of classroom teachers and students questionnaire. The whole system model is divided into application module, decision module and management module. These modules could transfer the data each other and analyze the data. The teachers, students and management decision-makers of college can use this system to know teachers and students’ feedback about knowledge, to control Learning discipline, to static students' daily performance and teaching evaluation.