Mineralogical composition of chromian spinel in chromitite and host peridotite from the Neyriz and Nain ophiolite in Zagros ophiolite belt shows that there are remarkable compositional variations between these two ophiolites. Combining with the lithological variations of the Central Iran ophiolites from NE (harzburgite dominate Nain ophiolite with limited and small-size chromitite pods) to SW (harzburgite–dunite dominate Neyriz ophiolite with large potential of high-Cr chromitites) reveals that the Neyriz chromitites from the Zagros southern sectors (outer Zagros) are the product of typical of fore-arc-related boninitic melts, whereas the Nain chromitites of the inner Zagros ophiolite belt are associated with the back-arc basin-related boninitic parentage with affinities to MORB-like melts.