Gene editing technology, as a revolutionary means of genetic engineering, has the ability to finely modify the genome of an organism, and to confer specific traits to an organism by altering specific gene sequences. In recent years, with the rapid development of gene editing technology, tools such as Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Nucleic acid endonucleases (TALENs), and the CRISPR/Cas9 system have been widely utilized for precise editing of endogenous genes in organisms. The application of this technology is also gradually expanding, not only limited to model organisms in the laboratory, but also extending to a wide range of animal species such as mice, zebrafish, pigs, cows, goats, sheep, rabbits, monkeys, and so on. Traditional breeding methods often require a lot of time and effort, and the emergence of gene editing technology provides a more efficient solution to this problem. Through gene editing technology, researchers can accurately edit genes related to disease resistance in the animal genome, thus breeding healthier, disease-resistant animal breeds. The aim of this paper is to explore in depth the application and prospects of gene editing technology in breeding domesticated animals for disease resistance. By analyzing actual cases of gene editing technology in different animal species, we can better understand the potential and advantages of this technology in enhancing disease resistance in animals. In addition, we will also explore the development trends and challenges of gene editing technology in the field of disease resistance breeding in the future. In summary, the continuous progress and application of gene editing technology will bring new hopes and opportunities in the field of disease resistance breeding in agricultural animals.