Facing the development needs of laser directed energy deposition surface modification and remanufacturing, the study revealed the influence mechanism of ultrasonic vibration direction on the laser directed energy deposition of Inconel718 parts, and provided a reference for the ultrasound-assisted high quality molding of laser directed energy deposition. Experiments on laser directed energy deposition of Inconel718 parts were carried out with multi-directional ultrasonic vibration, and the effects of ultrasonic vibration in the deposition direction, tangential direction and scanning direction on the flow behavior, microstructure and mechanical properties of the molten pool were studied by combining with in situ molten pool monitoring technology. Ultrasonic vibration in different directions significantly affected the dynamic flow behavior of the melt pool through inertial force and heat flow in different directions, among which ultrasonic vibration in tangential direction had excellent comprehensive ability in increasing the wetting area of the melt pool and improving the dynamic flowability of the melt pool. The scanning direction vibration had the best effect on grain refinement, while the spheroidization and reduction of Laves phase points were most obvious under the deposition direction vibration. The trend of microhardness enhancement under different vibration directions was consistent with the trend of grain size reduction. Under the influence of horizontal direction ultrasonic vibration, especially the scanning direction improved the strength of the material while maintaining the ductility to a certain extent; while in the lateral direction, the ultrasonic vibration assisted to show better anisotropy elimination ability, and excellent matching of hardness, strength and plasticity was obtained. Future research and applications can select the appropriate ultrasonic vibration direction or use it in combination to obtain excellent Inconel718 part properties according to specific demand objectives.