Because the bridges are in the deep water, so the influence on structural dynamic characteristics by the water body need to be considered. And the dynamic response of the structure is also affected by the long-term interaction between deep water and waves. At present, most of the research studies focus on deep-water bridge with the solid piers. However, there are few studies on the fluid-structure interaction of the deep-water bridge with the hollow piers under the action of earthquake, flowing water and wave. In this paper, a three-dimensional numerical flume is taken as the research object. Based on the regular wave theory and wave generation method of dynamic boundary conditions, the numerical waves with different wave parameters are numerically simulated. In order to avoid wave attenuation during its propagation and simulate the ideal wave, the method of appropriately amplifying the speed of wave plate is very effective. The hollow pier is used as the research object to analyze the dynamic response under current action, wave action, current action and wave action. The results show that the dynamic response of the pier is not the direct superposition of the single action of the current and the wave. In combination action, the influence of wave on the pier is dominant. The flowing water increases the effect of the wave crest on the pier, but reduces the effect of the wave trough on the pier.

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