In recent years, the continuous advancement of urbanization has brought about a series of problems. The automatic driving technology is getting more and more attention. However, the current automatic driving technology is only available under certain conditions. The drivers need to take over the vehicle in certain cases while they are involved in non-driving tasks. The driver's physiology and psychology will be affected under such condition, which increases the likelihood of accidents. The human-machine transition is an important part of the automated driving which has a fatal effect on driving safety. This research analyzed drivers’ physiology and psychology of human-machine transition in automatic driving by using the driving simulation technology. In this study, a simulating driving scenario was created. The driving simulator and the cardiotachometer were used in the experiment to test the physiological and psychological situation of different drivers under different non-driving tasks when they take over the vehicle. One-way analysis of variance was used to compare the differences between different groups of drivers. A series of take-over strategies were put forward to improve the safety of taking over. Keywords: Autonomous driving, human-machine transition, change of heart rate, differential analysis

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