The safe functioning of offshore liquid natural gas production depends on the transport behavior and its impact on the cryogenic pipeline. The thermal-fluid-solid coupling analysis of the LNG cryogenic corrugated flexible pipeline is investigated numerically in this paper. A three-dimensional pipeline model with multi-layer materials is built and a thermal-fluid-structure coupling framework is established in ANSYS. The flow transport behavior involving heat convection is assessed and structural response is analyzed. The numerical investigations show that the structure form of the entrance has an influence on the flow field distribution and the velocity in the entrance has the maximum. The pipe with multi-layer material is necessary to maintain LNG at low temperature, the maximum at temperature difference is located at the corrugated layer. while the thickness of each layer should be designed to ensure LNG in liquid state during transmission. The total deformation and strain are closely related to the constraint form of the hose and the inlet velocity. The simulation results provide valuable information on the response of the LNG cryogenic corrugated flexible pipeline in real application, making the LNG transportation process more reliable.