13 / 2021-09-08 21:09:33
Integrative analysis of specific subtypes defined by tumor immune microenvironment in hepatocellular carcinoma
hepatocellular carcinoma,immune microenvironment,immune subtypes,immune risk model
全文被拒
永康 王 / 安徽中医药大学
红星 阚 / 安徽中医药大学
Abstract—Due to the tumor heterogeneity and the diversity of the immune microenvironment, not all HCC patients could achieve the desired therapeutic effect from the immunotherapy. We identified three immune clusters with increasing ESTIMATE scores and redefined them as Cluster A (high immune), B (intermediate immune), and C (low immune) in HCC. Through the combination of the bulk and single-cell RNA-seq data, statistical differences of infiltrating immune cells, tumor mutational burden, and immune checkpoints were comprehensively explored to compare the diversity of immune microenvironment among clusters. Additionally, we constructed an immune risk model and validated its prognosis value for the survival prediction in HCC. This study identifies the specific subtypes through the tumor immune microenvironment and reflects the distinct tumor phenotype and detailed immune landscape in HCC. And it would provide new insights into immunotherapy and improve the clinical benefit for HCC treatment.

 
重要日期
  • 会议日期

    11月13日

    2021

    11月14日

    2021

  • 09月30日 2021

    报告提交截止日期

  • 11月14日 2021

    注册截止日期

主办单位
IEEE北京分会
中国生物医学工程学会医学物理分会
中国电子学会生命电子学分会
承办单位
中国科学技术大学
安徽省生物医学工程学会
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