Molecular mechanism underlying modulation of TRPV1 heat activation by polyols
编号:71 访问权限:仅限参会人 更新:2021-08-03 19:17:03 浏览:741次 张贴报告

报告开始:2021年08月07日 09:20(Asia/Shanghai)

报告时间:20min

所在会场:[S2] Poster session [Po] Poster session

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摘要
Sensing noxiously high temperatures is crucial for living organisms to avoid heat-induced injury. The TRPV1 channel has long been known as a sensor for noxious heat. However, the mechanism of how this channel is activated by heat remains elusive. Here we found that a series of polyols including sucrose, sorbitol, and hyaluronan significantly elevate the heat activation threshold temperature of TRPV1. The modulatory effects of these polyols were only observed when they were perfused extracellularly. Interestingly, mutation of residues E601 and E649 in the outer pore region of TRPV1 largely abolished the effects of these polyols. We further observed that intraplantar injection of polyols into the hind paws of rats reduced their heat-induced pain response. Our observations not only suggest that the extracellular regions of TRPV1 are critical for the modulation of heat activation by polyols, but also indicate a potential role of polyols in reducing heat-induced pain sensation.
 
关键词
TRPV1, polyols, heat activation, thermal activation threshold, outer pore region
报告人
NieYingying
Qingdao University

稿件作者
TianYuhua Qingdao University
NieYingying Qingdao University
LiuLei Qingdao University
杨帆 Zhejiang University
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重要日期
  • 会议日期

    08月06日

    2021

    08月09日

    2021

  • 08月09日 2021

    注册截止日期

主办单位
中国神经科学学会离子通道与受体分会
承办单位
河北工业大学
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