18 / 2021-10-08 21:30:35
Cytotoxicity assessment of metal complexes coordinated with marine alkaloid isoquinolin and ruthenium
marine alkaloid isoquinolin,ruthenium,3D multicellular tumor spheroid (MCTS)
摘要录用
陈锦灿 / 广东医科大学
唐红 / 广东医科大学
王杰 / 广东医科大学
陈兰美 / 广东医科大学
Anti-tumor is a major research direction of Marine alkaloids.A novel dimeric isoquinoline alkaloid, jorumycin, has been isolated from the Pacific nudibranch (Jorunna funebris) [1]. In addition, 3D multicellular tumor spheroid (MCTS) model has received increasing interest in recent years, since it can realistically mimics the extracellular matrix (ECM) and the in vivo situations and therefore have been widely applied in the drug discovery process [2]. In this work, we evaluated the cytotoxicities of novel  synthesised Ru(II)-IQ complexes RuIQ-3, RuIQ-4, and RuIQ-5 by MTT assay, 3D multicellular tumor spheroids(MCTSs) model and zebrafish embryos.And demonstrate that the new ruthenium complexes Ru-IQ3-Ru-IQ5 could effectively kill cancer cells, even the drug resistant cell, A549R. The 3D multicellular tumor spheroids (MCTSs) model also confirmed the good anti-tumor activity of Ru-IQ3-Ru-IQ5. Especially, Ru-IQ5 is expected to be a low-toxicity drug for lung cancer treatment because Ru-IQ5 does not induce embryonic toxicity or toxicity in zebrafish embryos and larvae during development at concentrations less than 16μM (13.6 μg/mL).

 
重要日期
  • 会议日期

    11月12日

    2021

    11月14日

    2021

  • 11月14日 2021

    注册截止日期

主办单位
中国药学会海洋药物专业委员会
中国生物化学与分子生物学学会海洋专业分会
中国微生物学会海洋微生物学专业委员会
中国海洋湖沼学会药物分会
承办单位
广西中医药大学
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