Non-invasive brain neuromodulation is indispensable to the study of brain function. It has also been proven effective for treating some neurological disorders. As a novel method for brain neuromodulation, Transcranial Magneto-Acousto-Electric Stimulation (TMAES) does not needs urgery and genetic alteration, it also owns higher spatial resolution and deeper penetration than other non-invasive methods such as transcranial direct current stimulation and transcranial magnetic stimulation. It has not been explored before although the intramembrane mechanoelectrical effect plays an important role in the firing activity of neuron. Membrane capacitance of neuronchanges under the function of ultrasonic radiation force. In this talk, we will show a multiscale model, and the neuron firing behaviors based on this model under the Magneto-Acousto-Electric effect are studied. How TMAES modulates neural firing activity will also be shown. The numerical experiment shows that parameter values of TMAES determine the current density, resulting in different firing behaviors and different neuron firing patterns. The results further highlight the role of Magneto-Acousto-Electric effect in neural excitation. They help illuminate sub-threshold and novel physical cellular effects, and may be useful in finding better methods for  real-time non-invasive neural control.

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