Spatial lifecourse epidemiology has emerged at the intersection of spatial science and lifecourse epidemiology in an era of big data. The interest of spatial lifecourse epidemiology is to know not only when and where disease occur, but also when, where, and how prior exposures occur, so we can investigate etiology and identify points of intervention. Spatial lifecourse epidemiology utilizes spatial, location-based, and artificial intelligence technologies to investigate long-term effects and mechanisms of measurable environmental, behavioral, psychosocial, and biological factors on individual disease risk at an unprecedented accuracy level. The International Initiative on Spatial Lifecourse Epidemiology (ISLE) has been established as a global transdisciplinary collaborative research network, to facilitate the design and implementation of spatial lifecourse epidemiologic research. Research activities conducted in ISLE will help to realize strategic global health goals, such as WHO Sustainable Development Goals, sustainable, healthy, smart cities.